
Welcome to the SIMBA-T Study
Surgical Site Infections in Major Lower Limb Amputation – Transmetatarsal Extension
Building on the success of the SIMBA audit, SIMBA-T is an international, multicenter study focused on improving outcomes in transmetatarsal amputations (TMAs). This study aims to:
- Investigate the incidence and risk factors of surgical site infections (SSIs) in TMAs.
Describe centre specific pathways and policies surrounding TMAs.
- Collect robust data to guide future clinical practices.


Chronic limb-threatening ischaemia (CLTI) and diabetes can lead to severe complications, necessitating transmetatarsal amputation (TMA). TMA offers advantages over major lower limb amputation (MLLA) by preserving limb length and allowing for a functioning ankle joint.
In the UK, 1,872 TMAs were performed in 2022-23, outcomes reporting for these procedures is inadequate. A systematic review identified a pooled SSI rate of 24% following TMA, but this was based on limited data with significant risk of bias.
To tackle these deficiencies, the SIMBA-T Audit will build upon the existing SIMBA framework, which recently provided valuable outcome data on approximately 1,000 MLLA patients.
– Get Involved –
Interested in joining the SIMBA-T study? Sign up now to play a vital role in advancing vascular surgery research.
- Recruitment starts: OPEN NOW
- Data collection starts: March 1 2025
📩 Contact Us
For questions or to register, reach out to the SIMBA-T team:
✉️ Email: simbat.amputation@gmail.com
